Anyone interested in transhuman sci-fi roleplaying should check out Eclipse Phase (produced by Posthuman Studios, published by Catalyst Games). Below is some info about the game:
Biotechnology allows people to genefix, enhance, and clone their bodies, while others pursue body modifications to adapt to new environments or make themselves into something no longer quite human. People’s minds and memories can be digitized, uploaded, transferred over long distances, and downloaded into new bodies (biological or synthetic). Death has been defeated—for those who can afford it.
Eclipse Phase uses a variant d100/percentile system with some twists. The game is fast and simple, streamlined so players can dive into the world and action without being burdened down by complex rules.
One really interesting facet is that it was released under the Creative Commons Attribution- Noncommercial-Share Alike 3.0 Unported License. What this means is that you can redistribute it with attribution as long as you don’t charge money for it and you attribute the original material to Posthuman Studio.
In an effort to drum up some players to maybe run a campaign you can get the quick-start rules and the core rule book here at FGS. If you are interested in playing then don’t read the adventure section of the quick-start rules as that would spoil your fun.